We are thrilled to inform you about the science of eye tracking. Every month, we will keep you updated on the latest news shared by the scientific community. The newsletter of this month is related to the analysis of eye movements for differential diagnosis of Multiple System Atrophy.
We are also excited to announce you that a first prototype of NeuroClues TM is ready! NeuroClues* is a portable lab that will help you instantaneously measure your clinical exam. Do not hesitate to contact us for a demo.
The P3Lab team
*The product is not yet available for sale and will soon undergo clinical investigations.
There is a wealth of scientific knowledge about eye movements analysis for the differential diagnosis of MSA. We list here a few examples:
Légende: PD: Idiopathic Parkinson’s Disease ; MSA: Multiple System Atrophy ; CBS: Corticobasal Syndrome; PSP: Progressive Supranuclear Palsy ; LBD: Lewy body Dementia; PDD: Parkinson’s Disease Dementia; ATD: Alzheimer’s type Dementia; PNFA: Progressive Nonfluent Aphasia; FTD/tau: Frontotemporal Dementia – tauopathies ; FTD/TDP: Frontotemporal Dementia: – Proteinopathies; sw : square waves ; dbn : downbeat nystagmus ; e.s. : express saccade
Adapté de Leigh, R. &. Zee (2015-06). The Neurology of Eye Movements. Oxford, UK: Oxford University Press.
From December 2019 to January 2021, 30 patients with PD and 23 patients with MSA (17 with cerebellar-type MSA and 6 with parkinsonian-type MSA) had a video-oculographic recording of HITs at two university hospitals in South Korea. Researchers found that reversed (p = 0.034) and perverted (p = 0.015) catch-up saccades were more frequently observed in MSA than in PD during HITs.
Saccades in MSAP are characterized both by prolonged acceleration and deceleration periodes with reduced peak velocity. In contrast, the velocity profile of PD patients was characterized mainly by prolonged deceleration period
Terao et al. in Clin NeuroPhysiol 2019According to recent findings, saccade profiles provide useful information for differentiating between PD and MSAP at early stages. While the changes in velocity profiles may be explained by the cerebellar and brainstem pathology in MSAP, the changes in velocity profile in both PD and MSAP correlated significantly with increasing severity of Parkinsonism in both disorders, suggesting a link with striatonigral pathology.
Inspection of the saccadic component of pursuit tracking revealed that in MSA saccades typically correct for position errors accumulated during SPEM epochs (“catch-up saccades”), whereas in PD, saccades were often directed toward future target positions (“anticipatory saccades”).
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