Extend your Cerebellar Assessment with Eye Movements

Cerebellar ataxia is a neurological disorder characterized by deficits in coordination, balance, and motor control resulting from damage to the cerebellum itself or to the cerebellar pathways.

CURRENT LIMITATIONS

Challenges in Cerebellar Assessment: Limited Sensitivity and Overlapping Symptoms

Medical Imaging Accuracy Analysis
Limitations

Sensitivity of current methods

While diagnosis typically involves clinical examination, imaging, and genetic testing, these approaches do not allow for objective and quantified functional assessment,  particularly in early or atypical cases and for longitudinal monitoring.

Cerebellar Motor Symptoms Illustration
Limitations

Symptoms overlapping

Cerebellar syndromes can be confused with other neurological diseases. This can complicate diagnosis, can delay appropriate intervention and can make the evaluation of treatment effectiveness difficult.

Eye movements abnormalities are hallmark features of cerebellar impairment and often precede overt motor symptoms1, 2, 3.

Saccadic impairment

Dysmetria (Hypermetria or Hypometria)

Ocular misalignment

Esophoria or Exophoria

Fixation impairment

Nystagmus and saccadic intrusions

Pursuit impairment

Jerky pursuit with catch-up saccades

Vestibular impairment

Impaired vestibulo-ocular reflex (VOR)

EP-038 Cerebellar structure Brochure_EN_v1.0 (4)

1 Leigh RJ, Zee DS. Disorders of Ocular Motility Due to Disease of the Brainstem, Cerebellum, and Diencephalon. In: Leigh RJ, Zee DS, eds. The Neurology of Eye Movements. Oxford University Press; 2015:0. doi:10.1093/med/9780199969289.003.0013

2 Bodranghien F, Bastian A, Casali C, et al. Consensus Paper: Revisiting the Symptoms and Signs of Cerebellar Syndrome. Cerebellum. 2016;15(3):369-391. doi:10.1007/s12311-015-0687-3

3 Manto M, Bower JM, Conforto AB, et al. Consensus Paper: Roles of the Cerebellum in Motor Control—The Diversity of Ideas on Cerebellar Involvement in Movement. Cerebellum. 2012;11(2):457-487. doi:10.1007/s12311-011-0331-9

BIOMARKER BASED APPROACH

Oculomotor assessment with neuroClues®

Table of oculomotor assessment of cerebellar syndrome with neuroClues & expected results
From Setup to Insight in Minutes

Objective and rapid oculomotor evaluation made simple with neuroClues®

neuroClues® offers a compact, non-invasive solution for monitoring eye movements in clinical practice in an objective and reproducible way. With minimal setup and no patient calibration, clinicians can perform standardized recordings of saccades, fixation, and pursuit in about 10 minutes. Biomarkers and timecourses are automatically computed and displayed next to reference ranges for simple interpretation and timely decisions.

Discover the neuroClues® platform
Female doctor staring at patient

Reason for Consultation

Suspected cerebellar syndrome.

Patient & doctor with neuroClues

neuroClues® Assessment

Execute selection of Protocols for Cerebellar assessment.

neuroClues patient report

Interpretation & decision

Evidence supporting the diagnostic hypothesis.

Examples of recording with neuroClues®

Hypermetric saccade neuroClues computer
1. Hypermetric saccade
Saccadic Pursuit neuroClues computer
2. Saccadic Pursuit
Gaze-evoked nystagmus on the left side view
3.  Gaze-evoked nystagmus on the left side view
Downbeat nystagmus in primary position
4.  Downbeat nystagmus in primary position
TAKE THE NEXT STEP

Book a demo or contact us to learn how neuroClues® can enhance your diagnostic workflow.

Book a demo

neuroClues is powered by P3Lab SRL
VAT: BE 0750.746.841

Centre Monnet – Av. Jean Monnet, 1 – 1348 Louvain-la-Neuve – Belgium
45 Rue du Jardin Public - 33000 Bordeaux - France

 

Our development is financed with the support of the Walloon Region and the European Innovation Council.Cofunded     wallonie_v_nb-Converted