Enhance differential diagnosis of idiopathic vs atypical parkinsonian syndromes with eye movements

1 in 5 people initially diagnosed with Parkinson disease will see their diagnosis of Parkinson’s disease being changed within 2 years.

PRECISION DIAGNOSIS

Recognizing Atypical Parkinsonism: the key to better prognosis & treatment planning.

Idiopathic Parkinson's disease (PD) is the most prevalent form of parkinsonism.
However, atypical variants account for up to 20% of cases 1,2.

MSA

Multiple System Atrophy

CBS

Corticobasal Syndrome

PSP

Progressive Supranuclear Palsy

LBD

Dementia with Lewy Bodies

Atypical forms tend to progress more rapidly, impacting prognosis, and respond poorly to dopaminergic therapy, influencing treatment planning.

1 Dauer, W., & Przedborski, S. (2003). Parkinson’s Disease: Mechanisms and Models. Neuron, 39(6), 889–909. https://doi.org/10.1016/s0896-6273(03)00568-3
2 (n.d.). Parkinson’s Disease vs. Parkinsonism. Parkinson.org. https://www.parkinson.org/sites/default/files/documents/parkinsons-vs-parkinsonisms.pdf

Clinical guidelines highlight “red flags” for atypical parkinsonism

Website_EN (7)
Early postural instability
Website_EN (8)
Rapid cognitive decline
Website_EN (9)
Poor levodopa response
Website_EN (10)
Oculomotor abnormalities
BIOMARKER BASED APPROACH

Comparison of oculomotor features across Parkinsonian Syndromes.

EP-023 neuroclues Parkinson Brochure_EN_v2.1 (4)

Anderson, T. J., & MacAskill, M. R. (2013). Eye movements in patients with neurodegenerative disorders. Nature Reviews Neurology, 9(2), 74–85. https://doi.org/10.1038/nrneurol.2012.273

Gaymard, B. (2013). Les mouvements oculaires: Intérêt de l’enregistrement des mouvements oculaires en clinique neurologique.

Kobylecki, C. (2020). Update on the diagnosis and management of Parkinson’s disease. Clinical Medicine, 20(4), 393–398. https://doi.org/10.7861/clinmed.2020-0220 

Leigh, R. John, and David S. Zee. “Disorders of Ocular Motility with Disease Affecting the Basal Ganglia, Cerebral Cortex, and in Systemic Conditions.” In The Neurology of Eye Movements, by R. John Leigh and David S. Zee. Oxford University Press, 2015. https://doi.org/10.1093/med/9780199969289.003.0014.

From Setup to Insight in Minutes

Objective and rapid oculomotor assessment made simple with neuroClues®.

neuroClues® offers a compact, non-invasive solution for monitoring eye movements in clinical practice in an objective and reproducible way. With minimal setup and no patient calibration, clinicians can perform standardized recordings of saccades, fixation, and pursuit in about 10 minutes. Biomarkers and timecourses are automatically computed and displayed next to reference ranges for simple interpretation and timely decisions.

Discover the neuroclues® platform
consultation

Reason for Consultation

Clinical parkinsonian syndrome with suspicion of atypical parkinsonian syndrome.

assessment

neuroClues® Assessment

Execute selection of Protocols for extrapyramidal evaluation

Healthy_Report_VGS Step Hor 16 200%

Interpretation & decision

Evidence supporting the diagnostic hypothesis

Examples of recording with neuroClues®

1. Correct Anti-saccade
1. Correct anti-saccade
2. Error Anti-saccade
2. Error anti-saccade
3. Smooth Pursuit
3. Smooth Pursuit
4. Saccadic Pursuit
4. Saccadic Pursuit (with catch up saccades & SWJ (red circles)
5. Main Sequence
5. Main sequence
TAKE THE NEXT STEP

Book a demo or contact us to learn how neuroClues® can enhance your diagnostic workflow.

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neuroClues is powered by P3Lab SRL
VAT: BE 0750.746.841

Centre Monnet – Av. Jean Monnet, 1 – 1348 Louvain-la-Neuve – Belgium
45 Rue du Jardin Public - 33000 Bordeaux - France

 

Our development is financed with the support of the Walloon Region and the European Innovation Council
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